We are specialized in the implementation of cutting-edge techniques allowing the recording of physiological data on the animal free of movement: electrophysiology, optogenetics, photometry.

Our interventions are deployed along 4 axes:

Equipment: purchase advice, sale of equipment and consumables, installation and troubleshooting.
Technical training: from the installation of the equipment, its handling, to the analysis of the data, including the manufacture of the electrodes.
Data provision: conducting experiments, collecting and analyzing data.
Tailor-made assistance: technical and scientific support on work in progress (data processing and analysis, programming, image analysis software)

To carry out its missions, Aquineuro relies on the experience of its three founders, PhDs in neuroscience, who have accumulated 30 years of scientific activity in the academic research system, and particularly in the field of electrophysiology, fiber photometry and optogenetics.

Thanks to close collaboration with INCIA (CNRS, UMR 5287) we have privileged access to the experimental facilities and resources essential to the development of our activity, as well as to rich scientific and technical interactions with the institute’s teams.

We put ourselves at the service of laboratories and research teams, by adapting our responses to their needs. We also devote a large part of our activity to the research and development of innovative solutions relating to techniques, equipment and software.

The 3 founders: Stéphane Valerio, Rémi Proville, Sébastien Delcasso

Stéphane Valerio

2007 : Thèse de neurosciences à Bordeaux en 2007 (sous la direction du Pr. R. Jaffard)
2008 : Dartmouth College (Hanover, USA). Recherche sur les cellules direction de la tête dans le laboratoire de de Jeffrey Taube.
2012 : Institut Magendie (Inserm, U1215), à Bordeaux, dans le laboratoire de Cyril Herry.

Publications :

Valerio S, Taube JS (2012) Path integration: how the head direction signal maintains and corrects spatial orientation. Nature Neuroscience.
Taube JS, Valerio S, Yoder RM (2013) Is navigation in virtual reality with fMRI really navigation? J Cogn Neurosci.
Rozeske RR, Valerio S, Chaudun F, Herry C. (2015) Prefrontal neuronal circuits of contextual fear conditioning. Genes Brain Behav. Jan;14(1):22-36.
Valerio S, Taube JS. Head Direction Cell Activity Is Absent in Mice without the Horizontal Semicircular Canals. J Neurosci. 2016 Jan 20;36(3):741-54.
Sellami A, Al Abed AS, Brayda-Bruno L, Etchamendy N, Valerio S, Oulé M, Pantaléon L, Lamothe V, Potier M, Bernard K, Jabourian M, Herry C, Mons N, Piazza PV, Eichenbaum H, Marighetto A. Temporal binding function of dorsal CA1 is critical for declarative memory formation. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10262-10267.

Sébastien Delcasso

2008 2007  : Thèse de neurosciences à Bordeaux sous la direction du Dr. Y. Cho.
2010  : National University (Séoul, Corée du Sud). Recherche sur la mémoire et les cellules de lieux, comparaison des systèmes de mémoire hippocampique et striatal sous la direction du Dr. I. Lee.
2012  : M.I.T (Cambridge, USA). Recherche sur le système striatal et sur la maladie de Huntintgon.
2017  : Institut Magendie (Inserm, U1215), à Bordeaux. Recherche sur les bases neuronales de l’anxiété dans le laboratoire d’ Anna Beyeler.

Publications :

Roman Serrat, Ana Covelo, Vladimir Kouskoff, Sebastien Delcasso, Andrea Ruiz, Nicolas Chenouard, Carol Stella, Corinne Blancard, Benedicte Salin, Francisca Julio-Kalajzić, Astrid Cannich, Federico Massa, Marjorie Varilh, Severine Deforges, Laurie M. Robin, Diego De Stefani, Arnau Busquets Garcia, Frederic Gambino, Anna Beyeler, Sandrine Pouvreau, Giovanni Marsicano. Astroglial calcium transfer from endoplasmic reticulum to mitochondria determines synaptic integration. BioRxiv 2020.12.08.415620
Friedman A, Hueske E, Drammis SM, Toro Arana SE, Nelson ED, Carter CW, Delcasso S, Rodriguez RX, Lutwak H, DiMarco KS, Zhang Q, Rakocevic LI, Hu D, Xiong JK, Zhao J, Gibb LG, Yoshida T, Siciliano CA, Diefenbach TJ, Ramakrishnan C, Deisseroth K, Graybiel AM. Striosomes Mediate Value-Based Learning Vulnerable in Age and a Huntington’s Disease Model. Cell. 2020 Nov 12;183(4).
S. Delcasso, S. Denagamage, Z. Britton, A.M. Graybiel. HOPE: Hybrid-Drive Combining Optogenetics, Pharmacology and Electrophysiology. Front Neural Circuits. 2018 May 16; 12:41.
C. Dagdeviren, K.B. Ramadi, P. Joe, K. Spencer, H.N. Schwerdt, H. Shimazu, S. Delcasso, K.I. Amemori, C. Nunez-Lopez, A.M. Graybiel, M.J. Cima, R. Langer. Miniaturized neural system for chronic, local intracerebral drug delivery. Sci Transl Med. 2018 Jan 24;10(425).
A. Friedman, D. Homma, B. Bloem, L.G. Gibb, K.I. Amemori KI, D. Hu, S. Delcasso, T.F. Truong, J. Yang, A.S. Hood, K.A. Mikofalvy, D.W. Beck, N. Nguyen, E.D. Nelson, S.E. Toro Arana, R.H. Vorder Bruegge, K.A. Goosens, A.M. Graybiel. Chronic Stress Alters Striosome-Circuit Dynamics, Leading to Aberrant Decision-Making. Cell. 2017 Nov 16;171(5):1191-1205
S. Delcasso, N. Huh, J.S. Byeon, J. Lee, M.W. Jung, I. Lee. Functional relationships between the hippocampus and dorsomedial striatum in learning a visual scene-based memory task in rats. Journal of Neuroscience. 2014 Nov; 34(47):15534-47.
S. Lagadec, L. Rotureau, A. Hemar, N. Macrez, S. Delcasso, Y. Jeantet and Y.H. Cho. Early temporal short-term memory deficits in double transgenic APP/PS1 mice. Neurobiology of aging. 2012 Jan; 33(1):203
S. Delcasso, J. Kim, and I. Lee. Neural correlates of object-in-place learning in hippocampus and prefrontal cortex. Journal of Neuroscience. 2011; 31(47):16991-7006.
S. Cayzac, S. Delcasso, Y. Jeantet and Y.H. Cho. Changes in striatal procedural memory coding correlate with learning deficits in a mouse model of Huntington’s disease. PNAS. 2011; 108(22):9280-5.
S. Delcasso, Y. Jeantet, Y.H. Cho. A new test for long-term declarative memory in an operant chamber in mice. Behavioural Brain Research. 2007; 178(1):200-207.
Y.H. Cho, S. Delcasso, A. Israel, Y. Jeantet. A long list visuo-spatial sequential learning in mice. Behavioural Brain Research. 2007; 179(1):152-158.
Y.H. Cho, S. Delcasso, Y. Jeantet. Item organization in three dimensional space and their discriminability in a mouse operant behavioral task. Behavioural Brain Research. 2006 ; 167(1):23-9.

Rémi Proville

2013: Thèse de neurosciences à l’École Normale Supérieure de Paris sous la direction du Dr Clément Léna
2014-2016 : Donders Institute – Radboud University (Nijmegen – Pays-Bas) : Étude de l’intégration sensorimotrice sous la direction du Pr. Tansu Celikel et Bernhard Englitz
2017-2018 : Institut Magendie (Inserm, U1215), à Bordeaux. Étude de l’hyperexcitabilité corticale dans un modèle de syndrome autistique, dans le laboratoire du Dr. Andreas Frick

Publications :

Heckman JJ, Proville R, Heckman GJ, Azarfar A, Celikel T, Englitz B – High-precision spatial localization of mouse vocalizations during social interaction – Scientific Report – 2017
Lea Ankri, Zoé Husson, Katarzyna Pietrajtis, Rémi Proville, Clément Léna, Yosef Yarom, Stéphane Dieudonné, Marylka Yoe Uusisaari – A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity – eLife – 2015
Rémi Proville, Maria Spolidoro, Nicolas Guyon, Philippe Isope, Clément Léna – “Cerebellum involvement in cortical sensorimotor circuits for the control of voluntary movements” – Nature Neuroscience – 2014